For example:
Fight Cub - A young man follows his dream of becoming a professional boxer, only to discover that instead of human opponents, he will actually be fighting young bears.
Hobo With a Shogun - Touching family comedy about a homeless traveller who makes friends with a time-travelling Japanese feudal lord
Full Meta Jacket - a satirical film that makes it a point to constantly reference itself and where the characters constantly break the fourth wall.
12 Angry Me - A man with dissociative identity disorder undergoes an internal battle where his 12 personalities argue amongst themselves about a personal mystery.
Eternal Sunshine of the Potless Mind - a documentary that follows a marijuana addict's battle to stop cold turkey.
Jurassic Ark - Before the flood, Noah faces a moral dilemma: Does he bring dinosaurs on the ark even though they'll eat some of the other animals, or does he leave the dinosaurs to die when the flood comes?
30 - A tiny group of Spartan soldiers try to fend off the Persian army. They are overpowered 20 minutes into the movie.
You get the idea