I can't imagine somebody on this site who hasn't seen a film by David Lynch. He is with little doubt, the most artistic American filmmaker working right now. (And by artistic I mean his image and sound work like a great painting, open to all kinds of interpretation.) He has his weird stuff and then his Really Weird Stuff. (A Straight Story was odd for coming off as quite normal.)
I was always kind of on the fence with Lynch, and after Lost Highway I thought I was through. But Mulholland Dr. pulled me back in and I really liked diving into Inland Empire, his most Lynchian film since Eraserhead. For those who don't like their cinema daring, love for Lynch probably stops at the border of "Twin Peaks", but I think Lynch is opening up new avenues for cinematic expression and he's not to be missed.
[It's worth noting that as the 80's came to a close, the two most acclaimed films of the decade were Raging Bull and Blue Velvet. I think now, most would clearly pick Scorsese. Might I suggest a Random Movie Deathmatch?]
[As long as I'm suggesting content, Lynch would also make for an interesting 'Director's Best/Director's Worst'.]