A duo of Breaking Baddies in Little Miss Sunshine: Walter White and Hand Schrader.
I don't know how the trifecta of White-Schrader-Saul can ever separate themselves and be Cranston-Norris-Odenkirk again. It's especially weird when Odenkirk pops up in stuff, because in my mind he's so clearly Saul Goodman, and I automatically laugh when I see him come up on screen. Like, I had no idea he was going to pop up in Little Women. When he did, I had to turn to my dad in the theater and say, Holy shit, it's Saul! It's actually kind of distracting.